They are rarely seen in PvP combat due to the difficulty procuring the blueprint and with Lance destroyers being far superior in firepower. Their blueprints are now obtainable in level 40-45 VEGA cargo fleets.
Siege drivers should only equip Iridium magnets when they are upgraded through the crafting system. Players should choose armor and strong shields instead. Avoid using Phased projectiles as they do not increase your firepower.
Scythes armed with Archer beams should equip focused optics. with Focus Optics V, they can easily out range SICO missile turrets, which are a very common base weapon that is quite powerful.
Arc Missiles can cause mass carnage, destroying compact bases and taking advantage of collateral damage. A similar if not greater amount of destruction can be achieved with Manifold missiles and higher level Creeper torpedoes.
Recharging shields such as Blast shields and Repulsor shields can be effective at enhancing the destroyer's survival in base combat if you can take advantage of the recharging. However, Metaphase shield III is also a solid option, as it can block any damage type, including those used by the Alien Hives' fighter swarms.
Equipping Strafe thrusters V can increase a destroyer's speed at repositioning themselves for sniping out combat modules and dodging projectiles when the decoys go down.
Some players may prefer equipping Armored Holds for extra armour.
The Scythe destroyers don't appear in any high level VEGA cargo fleets, however weaker versions without shields, known as the Claymore and Maul destroyers, appeared in level 25 antimatter cargo fleets and above, as well as level 30-35 VEGA cargo fleets.